Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

Author:

Bayliss Jill1,Mukherjee Piali2,Lu Chao3,Jain Siddhant U.4,Chung Chan1,Martinez Daniel5,Sabari Benjamin3,Margol Ashley S.6,Panwalkar Pooja1,Parolia Abhijit17,Pekmezci Melike8,McEachin Richard C.9,Cieslik Marcin17,Tamrazi Benita10,Garcia Benjamin A.11,La Rocca Gaspare12,Santi Mariarita5,Lewis Peter W.4,Hawkins Cynthia1314,Melnick Ari2,David Allis C.3,Thompson Craig B.12,Chinnaiyan Arul M.17,Judkins Alexander R.15,Venneti Sriram1

Affiliation:

1. Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.

2. Epigenomics Core Facility, Weill Medical College of Cornell University, New York, NY 10065, USA.

3. Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.

4. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.

5. Department of Pathology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

7. Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48104, USA.

8. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

9. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48104, USA.

10. Department of Radiology, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

11. Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

12. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

13. Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.

14. Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

15. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

Abstract

A subset of childhood posterior fossa ependymomas with poor prognosis is epigenetically similar to H3K27M gliomas.

Funder

National Cancer Institute

Matthew Larson Foundation

Sidney Kimmel Foundation

Doris Duke Foundation

Damon Runyon Cancer Research Foundation

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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