A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent-Reference-Cited by-同舟云学术

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Published:2018-05-23 Issue:442 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gioelli Noemi¹²^ORCID,Maione Federica²³^ORCID,Camillo Chiara¹²^ORCID,Ghitti Michela⁴^ORCID,Valdembri Donatella¹²^ORCID,Morello Noemi⁵^ORCID,Darche Marie⁶,Zentilin Lorena⁷,Cagnoni Gabriella¹²,Qiu Yaqi²³,Giacca Mauro⁷^ORCID,Giustetto Maurizio⁵⁸^ORCID,Paques Michel⁹¹⁰,Cascone Ilaria⁶,Musco Giovanna⁴^ORCID,Tamagnone Luca¹²,Giraudo Enrico²³^ORCID,Serini Guido¹²^ORCID

Affiliation:

1. Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.

2. Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Torino, Italy.

3. Department of Science and Drug Technology, University of Torino, 10125 Torino, Italy.

4. Biomolecular NMR Unit, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.

5. Department of Neuroscience, University of Torino School of Medicine, 10126 Torino, Italy.

6. Growth, Reparation and Tissue Regeneration Laboratory, ERL-CNRS 9215, University of Paris-Est, 94000 Créteil, France.

7. Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.

8. National Institute of Neuroscience-Italy, 10126 Torino, Italy.

9. Vision Institute, Sorbonne University, UPMC University of Paris 06, INSERM, CNRS, 75012 Paris, France.

10. Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, 75012 Paris, France.

Abstract

An NRP1-independent, non-natural SEMA3A mutant isoform is a parenterally deliverable anticancer drug that normalizes the vasculature.

Funder

Swiss National Science Foundation

Ministero della Salute

Associazione Italiana per la Ricerca sul Cancro

Fondazione Piemontese per la Ricerca sul Cancro - ONLUS

Associazione ‘Augusto per la Vita’

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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