Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

Author:

Neudecker Viola12ORCID,Brodsky Kelley S.1ORCID,Clambey Eric T.1ORCID,Schmidt Eric P.13,Packard Thomas A.4ORCID,Davenport Bennett1,Standiford Theodore J.5,Weng Tingting6,Fletcher Ashley A.7ORCID,Barthel Lea8ORCID,Masterson Joanne C.9ORCID,Furuta Glenn T.9ORCID,Cai Chunyan10ORCID,Blackburn Michael R.6,Ginde Adit A.111,Graner Michael W.12,Janssen William J.18ORCID,Zemans Rachel L.8ORCID,Evans Christopher M.17ORCID,Burnham Ellen L.7ORCID,Homann Dirk1,Moss Marc7,Kreth Simone2,Zacharowski Kai13ORCID,Henson Peter M.14,Eltzschig Holger K.114

Affiliation:

1. Organ Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.

2. Department of Anesthesiology, University Hospital, Ludwig-Maximilian University of Munich, 81377 Munich, Germany.

3. Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.

4. Department of Immunology and Microbiology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.

5. Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

6. Department of Biochemistry and Molecular Biology, University of Texas–Houston Medical School, Houston, TX 77030, USA.

7. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.

8. Department of Medicine, National Jewish Health, Denver, CO 80206, USA.

9. Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, Digestive Health Institute, Children’s Hospital Colorado; Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.

10. Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

11. Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.

12. Department of Neurosurgery, University of Colorado Denver, Aurora, CO 80045, USA.

13. Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany.

14. Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Abstract

Intercellular transfer of miR-223 from neutrophils to alveolar epithelial cells reduces lung inflammation in a mouse model of ventilator-induced lung injury or pulmonary bacterial infection.

Funder

National Institutes of Health

American Heart Association

Crohn’s and Colitis Foundation of America

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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