Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy-Reference-Cited by-同舟云学术

Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy

Published:2018-06-27 Issue:447 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Thannickal Thomas C.¹²^ORCID,John Joshi¹²^ORCID,Shan Ling¹²^ORCID,Swaab Dick F.³^ORCID,Wu Ming-Fung¹²^ORCID,Ramanathan Lalini¹²^ORCID,McGregor Ronald¹²^ORCID,Chew Keng-Tee¹²^ORCID,Cornford Marcia⁴,Yamanaka Akihiro⁵,Inutsuka Ayumu⁵^ORCID,Fronczek Rolf⁶⁷^ORCID,Lammers Gert Jan⁶⁷,Worley Paul F.⁸,Siegel Jerome M.¹²^ORCID

Affiliation:

1. Neuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Neurobiology Research, Veterans Administration Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA.

3. Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.

4. Department of Pathology, Harbor University of California, Los Angeles, Medical Center, Torrance, CA 90509, USA.

5. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

6. Leiden University Medical Centre, Department of Neurology, Leiden, Netherlands.

7. Sleep Wake Centre, Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands.

8. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Heroin addiction is accompanied by an increase in detected hypocretin (orexin) neurons, and in narcoleptic mice deficient in these neurons, morphine can reverse cataplexy.

Funder

NIH Office of the Director

U.S. Department of Veterans Affairs

The Brain & Behaviour Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

1. Centers for Disease Control and Prevention (CDC 2017); www.cdc.gov/drugoverdose/epidemic/.

2. Orexin/hypocretin role in reward: implications for opioid and other addictions

3. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction