Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis-Reference-Cited by-同舟云学术

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

Published:2018-10-24 Issue:464 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Scott Nicholas A.¹²^ORCID,Andrusaite Anna³^ORCID,Andersen Peter⁴,Lawson Melissa⁵^ORCID,Alcon-Giner Cristina⁵,Leclaire Charlotte⁵,Caim Shabhonam⁵,Le Gall Gwenaelle⁵^ORCID,Shaw Tovah¹²^ORCID,Connolly James P. R.³,Roe Andrew J.³^ORCID,Wessel Hannah³,Bravo-Blas Alberto³^ORCID,Thomson Carolyn A.³^ORCID,Kästele Verena³^ORCID,Wang Ping¹^ORCID,Peterson Daniel A.⁴⁶,Bancroft Allison¹⁷^ORCID,Li Xuhang⁴^ORCID,Grencis Richard¹⁷^ORCID,Mowat Allan McI³^ORCID,Hall Lindsay J.⁵^ORCID,Travis Mark A.¹²⁷^ORCID,Milling Simon W. F.³^ORCID,Mann Elizabeth R.¹²³^ORCID

Affiliation:

1. Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.

2. Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.

3. Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

4. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK.

6. Eli Lilly and Company, Indianapolis, 46285 IN, USA.

7. Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.

Abstract

Antibiotics disrupt intestinal immunity in mice.

Funder

National Institutes of Health

Wellcome Trust

Medical Research Council

Biotechnology and Biological Sciences Research Council

Publisher