TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy-Reference-Cited by-同舟云学术

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

Published:2018-05-02 Issue:439 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lim So-Yon¹^ORCID,Osuna Christa E.¹^ORCID,Hraber Peter T.²^ORCID,Hesselgesser Joe³,Gerold Jeffrey M.⁴^ORCID,Barnes Tiffany L.³^ORCID,Sanisetty Srisowmya¹^ORCID,Seaman Michael S.¹^ORCID,Lewis Mark G.⁵^ORCID,Geleziunas Romas³,Miller Michael D.³,Cihlar Tomas³,Lee William A.³,Hill Alison L.⁴^ORCID,Whitney James B.¹⁶^ORCID

Affiliation:

1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

3. Gilead Sciences Inc., Foster City, CA 94404, USA.

4. Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.

5. Bioqual, Rockville, MD 20852, USA.

6. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.

Abstract

SIV-infected rhesus macaques on antiretroviral therapy experienced a reduction in the SIV reservoir after treatment with TLR7 agonists.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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