Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma-Reference-Cited by-同舟云学术

Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma

Published:2018-05-16 Issue:441 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lochmann Timothy L.¹^ORCID,Powell Krista M.¹,Ham Jungoh¹,Floros Konstantinos V.¹^ORCID,Heisey Daniel A. R.¹^ORCID,Kurupi Richard I. J.¹,Calbert Marissa L.¹,Ghotra Maninderjit S.¹,Greninger Patricia²,Dozmorov Mikhail³^ORCID,Gowda Madhu⁴,Souers Andrew J.⁵,Reynolds C. Patrick⁶^ORCID,Benes Cyril H.²^ORCID,Faber Anthony C.¹^ORCID

Affiliation:

1. Virginia Commonwealth University Philips Institute, School of Dentistry and Massey Cancer Center, Richmond, VA 23298, USA.

2. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

3. Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA.

4. Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Children’s Hospital of Richmond at Virginia Commonwealth University, Richmond, VA 23298, USA.

5. AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA.

6. Cancer Center, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA.

Abstract

High-throughput screening identified hypersensitivity of neuroblastomas to H3K27 demethylation inhibition.

Funder

National Institutes of Health

Alex’s Lemonade Stand Foundation for Childhood Cancer

Wellcome Trust

Cure4Cam Childhood Cancer Foundation

I Care I Cure Childhood Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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