PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

Author:

Legchenko Ekaterina1ORCID,Chouvarine Philippe1,Borchert Paul1,Fernandez-Gonzalez Angeles2,Snay Erin3ORCID,Meier Martin4ORCID,Maegel Lavinia567,Mitsialis S. Alex2,Rog-Zielinska Eva A.8,Kourembanas Stella2,Jonigk Danny567,Hansmann Georg1ORCID

Affiliation:

1. Department of Pediatric Cardiology and Critical Care, Pulmonary Vascular Research Center, Hannover Medical School, Hannover, Germany.

2. Division of Newborn Medicine, Department of Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

3. Division of Nuclear Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

4. Small Animal Imaging Center, Laboratory Animal Science, Hannover Medical School, Hannover, Germany.

5. Institute of Pathology, Hannover Medical School, Hannover, Germany.

6. Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hannover, Germany.

7. The German Center for Lung Research (Deutsches Zentrum für Lungenforschung DZL), Giessen, Germany.

8. Institute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center–University of Freiburg, and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Abstract

Oral pioglitazone reverses pulmonary hypertensive vascular disease and prevents right heart failure via epigenetic, transcriptional, and metabolic mechanisms.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Kinderherzen e.V.

Stiftung KinderHerz

European Pediatric PVD Network

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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