PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN- λ production

Author:

Werder Rhiannon B.1ORCID,Lynch Jason P.1,Simpson Jennifer C.12ORCID,Zhang Vivian2,Hodge Nick H.1ORCID,Poh Matthew3ORCID,Forbes-Blom Elizabeth4,Kulis Christina5,Smythe Mark L.5,Upham John W.6ORCID,Spann Kirsten78ORCID,Everard Mark L.3,Phipps Simon27ORCID

Affiliation:

1. School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia.

2. Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston 4006, Australia.

3. School of Paediatrics and Child Health, University of Western Australia, Western Australia 6840, Australia.

4. Malaghan Institute of Medical Research, Wellington 6242, New Zealand.

5. Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia.

6. Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Queensland 4102, Australia.

7. Australian Infectious Diseases Research Centre, University of Queensland, Queensland 4067, Australia.

8. School of Biomedical Sciences, Queensland University of Technology, Queensland 4001, Australia.

Abstract

RSV-induced prostaglandin D2 release contributes to disease severity by impairing IFN-λ production.

Funder

Australian Infectious Disease Research Excellence Award

NHRMRC Development grant

Australian Research Council Future Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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