Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus-Reference-Cited by-同舟云学术

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

Published:2018-09-05 Issue:457 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Clave Emmanuel¹²^ORCID,Araujo Itauá Leston¹²,Alanio Cécile³⁴⁵,Patin Etienne⁶⁷⁸^ORCID,Bergstedt Jacob⁹,Urrutia Alejandra³⁴⁵¹⁰^ORCID,Lopez-Lastra Silvia⁵¹¹^ORCID,Li Yan⁵¹¹,Charbit Bruno³^ORCID,MacPherson Cameron Ross³^ORCID,Hasan Milena³,Melo-Lima Breno Luiz¹²^ORCID,Douay Corinne¹²,Saut Noémie¹²¹³^ORCID,Germain Marine¹⁴¹⁵,Trégouët David-Alexandre¹⁴¹⁵^ORCID,Morange Pierre-Emmanuel¹²¹³,Fontes Magnus¹⁰¹⁶,Duffy Darragh³⁴⁵^ORCID,Di Santo James P.⁵¹¹^ORCID,Quintana-Murci Lluis⁶⁷⁸^ORCID,Albert Matthew L.³⁴⁵¹⁰^ORCID,Toubert Antoine¹²¹⁷,

Affiliation:

1. Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d’Hématologie, 75010 Paris, France.

2. INSERM, UMRS-1160, Alloimmunity-Autoimmunity-Transplantation, 75010 Paris, France.

3. Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France.

4. Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France.

5. INSERM, UMRS-1223, 75015 Paris, France.

6. Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.

7. CNRS UMR-2000, 75015 Paris, France.

8. Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France.

9. Department of Automatic Control, Lund University, Lund SE-221, Sweden.

10. Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.

11. Innate Immunity Unit, Institut Pasteur, 75015 Paris, France.

12. Laboratory of Haematology, La Timone Hospital, 13005 Marseille, France.

13. Aix Marseille University, INSERM, UMRS-1260, INRA U1260, Center for Cardiovascular and Nutrition Research (C2VN), 13005 Marseille, France.

14. Sorbonne Université, Université Paris 6/UPMC, INSERM, UMRS-1166, Genomics and Pathophysiology of Cardiovascular Diseases, 75013 Paris, France.

15. Institute for Cardiometabolism and Nutrition, 75013 Paris, France.

16. International Group for Data Analysis, Institut Pasteur, 75015 Paris, France.

17. Laboratoire d’Immunologie et d’Histocompatibilité, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.

Abstract

Aging, sex, and genetics substantially affect human thymic function.

Funder

Agence Nationale de la Recherche

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. The golden anniversary of the thymus

2. Selection of Self-Reactive T Cells in the Thymus

3. Aire

4. Thymus involution and regeneration: two sides of the same coin?

5. Thymic involution and rising disease incidence with age

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