Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress-Reference-Cited by-同舟云学术

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress

Published:2018-05-09 Issue:440 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Seltmann Kristin¹^ORCID,Meyer Michael¹^ORCID,Sulcova Jitka¹,Kockmann Tobias¹²,Wehkamp Ulrike³,Weidinger Stephan³^ORCID,auf dem Keller Ulrich¹^ORCID,Werner Sabine¹^ORCID

Affiliation:

1. Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland.

2. Functional Genomics Center Zurich, ETH Zurich/University of Zurich, 8057 Zurich, Switzerland.

3. Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

Abstract

High environmental humidity rescues atopic dermatitis-like signs in mice, and CLCA2 protects the epidermis from hyperosmotic stress.

Funder

Ernst Schering Foundation

Swiss National Science Foundation

ETH Zurich

Leopoldina

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

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3. Atopic dermatitis

4. Tight junction defects in patients with atopic dermatitis

5. Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis

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