Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice-Reference-Cited by-同舟云学术

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Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

Published:2018-05-16 Issue:441 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Alawieh Ali¹²^ORCID,Langley E. Farris¹,Tomlinson Stephen¹³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Medical Scientist Training Program, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

3. Ralph H. Johnson VA Medical Center, Charleston, SC 29425, USA.

Abstract

Local inhibition of complement activation after stroke in mice prevents degenerative microglial activation and improves chronic recovery.

Funder

National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Complement in disease: a defence system turning offensive

2. Complement in the Homeostatic and Ischemic Brain

3. Injury site-specific targeting of complement inhibitors for treating stroke

4. Complement activation in the injured central nervous system: another dual-edged sword?

5. Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

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1. Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke;PLOS ONE;2024-08-07

2. Phosphorus Dendrimers Co‐deliver Fibronectin and Edaravone for Combined Ischemic Stroke Treatment via Cooperative Modulation of Microglia/Neurons and Vascular Regeneration;Advanced Healthcare Materials;2024-08-05

3. Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators;Frontiers in Immunology;2024-05-16

4. Complement Proteins in Serum Astrocyte-Derived Exosomes Are Associated with Poststroke Cognitive Impairment in Type 2 Diabetes Mellitus Patients;Journal of Alzheimer's Disease;2024-04-30

5. Complement propagates visual system pathology following traumatic brain injury;Journal of Neuroinflammation;2024-04-17

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