Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy-Reference-Cited by-同舟云学术

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

Published:2021-02-17 Issue:581 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chelko Stephen P.¹²^ORCID,Keceli Gizem²^ORCID,Carpi Andrea³,Doti Nunzianna⁴^ORCID,Agrimi Jacopo²,Asimaki Angeliki⁵^ORCID,Beti Carlos Bueno⁵,Miyamoto Matthew²^ORCID,Amat-Codina Nuria²,Bedja Djahida²⁶^ORCID,Wei An-Chi²^ORCID,Murray Brittney²^ORCID,Tichnell Crystal²,Kwon Chulan²,Calkins Hugh²,James Cynthia A.²^ORCID,O’Rourke Brian²^ORCID,Halushka Marc K.⁷^ORCID,Melloni Edon⁸,Saffitz Jeffrey E.⁹^ORCID,Judge Daniel P.²¹⁰^ORCID,Ruvo Menotti⁴^ORCID,Kitsis Richard N.¹¹^ORCID,Andersen Peter²^ORCID,Di Lisa Fabio³,Paolocci Nazareno²³^ORCID

Affiliation:

1. Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.

2. Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

3. Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.

4. Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.

5. Molecular and Clinical Sciences Research Institute, St. George’s, University of London, London WC1E 6BS, UK.

6. Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.

7. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

8. Department of Medicine, University of Genova, Genova 16126, Italy.

9. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 20115, USA.

10. Medical University of South Carolina, Charleston, SC 29425, USA.

11. Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Exercise-induced activation of calpain and nuclear translocation of calpain-cleaved apoptotic factor AIF triggers cardiomyocyte death in ACM.

Funder

National Institutes of Health

American Heart Association

Magic That Matters Fund

Fondation Leducq

Maryland Stem Cell Research Fund

Gilead Foundation

University of Padova Strategico Grant

Heart Rhythm Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference105 articles.

1. Heart Disease and Stroke Statistics—2009 Update

2. Sudden Deaths in Young Competitive Athletes

3. Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease

4. Exercise Increases Age-Related Penetrance and Arrhythmic Risk in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy–Associated Desmosomal Mutation Carriers

5. Exercise has a Disproportionate Role in the Pathogenesis of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in Patients Without Desmosomal Mutations

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