Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy-Reference-Cited by-同舟云学术

Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

Published:2021-09-22 Issue:612 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kohela Arwa¹^ORCID,van Kampen Sebastiaan J.¹^ORCID,Moens Tara¹,Wehrens Martijn¹^ORCID,Molenaar Bas¹,Boogerd Cornelis J.¹^ORCID,Monshouwer-Kloots Jantine¹,Perini Ilaria¹,Goumans Marie José²^ORCID,Smits Anke M.²^ORCID,van Tintelen J. Peter³^ORCID,van Rooij Eva¹⁴^ORCID

Affiliation:

1. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), 3584 CT Utrecht, Netherlands.

2. Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

3. Department of Genetics, University Medical Centre Utrecht, 3584 CX Utrecht, Netherlands.

4. Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, Netherlands.

Abstract

Modeling ACM using human-induced pluripotent stem cells shows that epicardial disruption of the desmosome drives cardiac fibro-fatty remodeling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. Arrhythmogenic Right Ventricular Cardiomyopathy

2. Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members

3. Arrhythmogenicity of fibro-fatty infiltrations

4. Arrhythmogenic right ventricular cardiomyopathy/dysplasia

5. Molecular mechanisms of arrhythmogenic cardiomyopathy

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