Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas

Author:

Sweha Stefan R.12ORCID,Chung Chan13ORCID,Natarajan Siva Kumar14ORCID,Panwalkar Pooja1ORCID,Pun Matthew156ORCID,Ghali Amer1ORCID,Bayliss Jill1ORCID,Pratt Drew17ORCID,Shankar Anand8,Ravikumar Visweswaran8ORCID,Rao Arvind8910ORCID,Cieslik Marcin78,Wilder-Romans Kari10,Scott Andrew J.10ORCID,Wahl Daniel R.10,Jessa Selin1112ORCID,Kleinman Claudia L.1213,Jabado Nada1314ORCID,Mackay Alan15ORCID,Jones Chris15ORCID,Martinez Daniel16ORCID,Santi Mariarita16,Judkins Alexander R.17ORCID,Yadav Viveka Nand18,Qin Tingting8,Phoenix Timothy N.19ORCID,Koschmann Carl J.18,Baker Suzanne J.20ORCID,Chinnaiyan Arul M.721ORCID,Venneti Sriram127ORCID

Affiliation:

1. Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

2. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

3. Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.

4. Molecular and Cellular Pathology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

5. Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

6. Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

7. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

8. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

9. Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.

10. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

11. Quantitative Life Sciences, McGill University, Montreal, Quebec H3A 2A7, Canada.

12. Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

13. Department of Human Genetics, McGill University, Montreal, Quebec H3A 0C7, Canada.

14. Department of Pediatrics, McGill University, and Research Institute of McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

15. Division of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.

16. Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

17. Department of Pathology, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA.

18. Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

19. Division of Pharmaceutical Sciences, College of Pharmacy, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

20. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

21. Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Histone H3.3G34R/V mutant gliomas demonstrate LIF/STAT pathway activation that can be disrupted for therapeutic benefit.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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