High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages-Reference-Cited by-同舟云学术

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Published:2021-06-02 Issue:596 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hoepel Willianne¹²^ORCID,Chen Hung-Jen³^ORCID,Geyer Chiara E.¹²^ORCID,Allahverdiyeva Sona¹²⁴,Manz Xue D.⁵^ORCID,de Taeye Steven W.⁴⁶⁷^ORCID,Aman Jurjan⁵,Mes Lynn¹²⁴^ORCID,Steenhuis Maurice⁶^ORCID,Griffith Guillermo R.³^ORCID,Bonta Peter I.⁸^ORCID,Brouwer Philip J.M.⁴^ORCID,Caniels Tom G.⁴^ORCID,van der Straten Karlijn⁴⁹^ORCID,Golebski Korneliusz¹⁰,Jonkers René E.⁸,Larsen Mads D.⁷^ORCID,Linty Federica⁷,Nouta Jan¹¹,van Roomen Cindy P.A.A.³,van Baarle Frank E.H.P.¹²,van Drunen Cornelis M.¹³,Wolbink Gertjan⁶¹⁴^ORCID,Vlaar Alexander P.J.¹²^ORCID,de Bree Godelieve J.⁹^ORCID,Sanders Rogier W.⁴¹⁵^ORCID,Willemsen Lisa³^ORCID,Neele Annette E.³^ORCID,van de Beek Diederik¹⁶^ORCID,Rispens Theo⁶^ORCID,Wuhrer Manfred¹¹^ORCID,Bogaard Harm Jan⁵^ORCID,van Gils Marit J.⁴^ORCID,Vidarsson Gestur⁷^ORCID,de Winther Menno³^ORCID,den Dunnen Jeroen¹²^ORCID

Affiliation:

1. Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Amsterdam Rheumatology and Immunology Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

2. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

3. Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

4. Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

5. Department of Pulmonary Medicine, Amsterdam UMC, location VUMC, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands.

6. Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands.

7. Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands.

8. Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

9. Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

10. Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

11. Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 AZ Leiden, Netherlands.

12. Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

13. Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

14. Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Admiraal Helfrichstraat 1, 1056 AA Amsterdam, Netherlands.

15. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

16. Departments of Neurology and Neuroscience, University of Amsterdam, Meibergdreef, Amsterdam UMC, Amsterdam, Netherlands.

Abstract

High titers and low fucosylation of human anti–spike protein IgG promote alveolar macrophage activation and inflammation.

Funder

H2020 Marie Skłodowska-Curie Actions

Fondation Leducq

University of Amsterdam

ZonMW

Netherlands Heart Foundation

European Union ITN

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference77 articles.

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3. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

4. Cytokine Storms: Understanding COVID-19

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