Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settings

Author:

Cleary Brian1ORCID,Hay James A.23ORCID,Blumenstiel Brendan1,Harden Maegan1,Cipicchio Michelle1ORCID,Bezney Jon1ORCID,Simonton Brooke1ORCID,Hong David4ORCID,Senghore Madikay2ORCID,Sesay Abdul K.5ORCID,Gabriel Stacey1,Regev Aviv678ORCID,Mina Michael J.1239ORCID

Affiliation:

1. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

2. Centre for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

3. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

4. Wharton Statistics, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, P.O. Box 273, Banjul, The Gambia.

6. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

7. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

8. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

9. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02120, USA.

Abstract

Simple group testing designs to improve SARS-CoV-2 surveillance in resource-constrained settings are identified using modeling and experimental data.

Funder

National Institutes of Health

National Institute of General Medical Sciences

Wharton School, University of Pennsylvania

National Science Foundation

Merkin Institute Fellowship at the Broad Institute of MIT and Harvard

NSF BIGDATA grant IIS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference43 articles.

1. World Health Organization “Weekly epidemiological update - 5 January 2021” (World Health Organization 2021); www.who.int/publications/m/item/weekly-epidemiological-update---5-january-2021.

2. World Health Organization “Critical preparedness readiness and response actions for COVID-19” (World Health Organization 2020); www.who.int/publications/i/item/critical-preparedness-readiness-and-response-actions-for-covid-19.

3. Diagnostic Testing for Severe Acute Respiratory Syndrome–Related Coronavirus 2

4. Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020

5. Interrupting transmission of COVID-19: lessons from containment efforts in Singapore

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