Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges-Reference-Cited by-同舟云学术

Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges

Published:2022-03-02 Issue:634 Volume:14 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Schmidt Jenna K.¹^ORCID,Jones Kathryn M.¹^ORCID,Van Vleck Trevor¹^ORCID,Emborg Marina E.¹²^ORCID

Affiliation:

1. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.

2. Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.

Abstract

Genetic modification of the embryo or germ line of nonhuman primates is envisioned as a method to develop improved models of human disease, yet the promise of such animal models remains unfulfilled. Here, we discuss current methods and their limitations for producing nonhuman primate genetic models that faithfully genocopy and phenocopy human disease. We reflect on how to ethically maximize the translational relevance of such models in the search for new therapeutic strategies to treat human disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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