Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma-Reference-Cited by-同舟云学术

Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma

Published:2022-01-12 Issue:627 Volume:14 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Headland Sarah E.¹^ORCID,Dengler Hart S.¹^ORCID,Xu Daqi¹,Teng Grace¹,Everett Christine²^ORCID,Ratsimandresy Rojo A.¹,Yan Donghong³^ORCID,Kang Jing³^ORCID,Ganeshan Kirthana¹,Nazarova Evgeniya V.¹^ORCID,Gierke Sarah⁴⁵,Wedeles Christopher J.¹,Guidi Riccardo¹^ORCID,DePianto Daryle J.¹^ORCID,Morshead Katrina B.¹^ORCID,Huynh Alison⁶,Mills Jessica⁶,Flanagan Sean⁶^ORCID,Hambro Shannon⁶^ORCID,Nunez Victor⁶^ORCID,Klementowicz Joanna E.⁷^ORCID,Shi Yongchang²^ORCID,Wang Jianyong²^ORCID,Bevers Jack⁸^ORCID,Ramirez-Carrozzi Vladimir¹^ORCID,Pappu Rajita¹,Abbas Alex⁹^ORCID,Vander Heiden Jason⁹^ORCID,Choy David F.¹⁰^ORCID,Yadav Rajbharan¹¹^ORCID,Modrusan Zora¹²,Panettieri Reynold A.¹³^ORCID,Koziol-White Cynthia¹³^ORCID,Jester William F.¹³^ORCID,Jenkins Brendan J.¹⁴¹⁵,Cao Yi⁹,Clarke Christine⁹^ORCID,Austin Cary⁵^ORCID,Lafkas Daniel¹^ORCID,Xu Min³^ORCID,Wolters Paul J.¹⁶^ORCID,Arron Joseph R.¹^ORCID,West Nathaniel R.⁷^ORCID,Wilson Mark S.¹^ORCID

Affiliation:

1. Immunology Discovery,Genentech Inc., South San Francisco, CA 94080, USA.

2. Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.

3. Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.

4. Center for Advanced Light Microscopy, Genentech Inc., South San Francisco, CA 94080, USA.

5. Pathology, Genentech Inc., South San Francisco, CA 94080, USA.

6. Necropsy, Genentech Inc., South San Francisco, CA 94080, USA.

7. Cancer Immunology Discovery, Genentech Inc., South San Francisco, CA 94080, USA.

8. Antibody Discovery, Genentech Inc., South San Francisco, CA 94080, USA.

9. OMNI Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.

10. Biomarker Discovery OMNI, Genentech Inc., South San Francisco, CA 94080, USA.

11. Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, CA 94080, USA.

12. Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

13. Rutgers Institute for Translational Medicine and Science, State University of New Jersey, New Brunswick, NJ 08901, USA.

14. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

15. Department of Molecular Translational Science, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Victoria 3800, Australia.

16. Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.

Abstract

Bacterial-associated LPS drives oncostatin M–dependent airway inflammation and mucus hypersecretion in severe asthma.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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1. Type 2 inflammation in asthma — present in most, absent in many

2. Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

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