TRIB3 reduces CD8<sup>+</sup>T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer-Reference-Cited by-同舟云学术

TRIB3 reduces CD8⁺T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer

Published:2022-01-05 Issue:626 Volume:14 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shang Shuang¹^ORCID,Yang Yu-wei¹^ORCID,Chen Fei¹^ORCID,Yu Liang²^ORCID,Shen Shuo-hao²,Li Ke³^ORCID,Cui Bing¹,Lv Xiao-Xi¹,Zhang Cheng¹,Yang Chen¹,Liu Jing¹,Yu Jiao-jiao¹,Zhang Xiao-wei¹^ORCID,Li Ping-ping¹^ORCID,Zhu Sheng-tao⁴,Zhang Hai-zeng²^ORCID,Hua Fang¹^ORCID

Affiliation:

1. Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China.

2. Department of Colorectal Surgery, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.

3. NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China.

4. Beijing Digestive Diseases Center, Beijing Friendship Hospital, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, P.R. China.

Abstract

TRIB3 promotes exclusion of CD8+T cells and enhances immune evasion by inhibiting the STAT1-CXCL10 signaling axis in colorectal cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. Immunotherapy in colorectal cancer: rationale, challenges and potential

2. Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

3. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

4. Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival

5. Cold Tumors: A Therapeutic Challenge for Immunotherapy

Cited by 74 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3;Computational and Structural Biotechnology Journal;2024-12

2. IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth;Biomedicine & Pharmacotherapy;2024-10

3. Epigenetics and immunotherapy in colorectal cancer: progress and promise;Clinical Epigenetics;2024-09-10

4. Emerging Roles of CircRNA-miRNA Networks in Cancer Development and Therapeutic Response;Non-coding RNA Research;2024-09

5. Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets;Experimental Hematology & Oncology;2024-08-30