Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice-Reference-Cited by-同舟云学术

Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice

Published:2021-07-28 Issue:604 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yong Jing¹²^ORCID,Parekh Vishal S.¹³^ORCID,Reilly Shannon M.³²^ORCID,Nayak Jonamani¹²,Chen Zhouji¹²,Lebeaupin Cynthia¹³²^ORCID,Jang Insook¹²^ORCID,Zhang Jiangwei⁴⁵,Prakash Thazha P.⁴⁵^ORCID,Sun Hong⁴⁵,Murray Sue⁴⁵^ORCID,Guo Shuling⁴⁵^ORCID,Ayala Julio E.⁵⁶^ORCID,Satin Leslie S.¹³,Saltiel Alan R.³²⁷^ORCID,Kaufman Randal J.¹^ORCID

Affiliation:

1. Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

2. Division of Metabolism and Endocrinology, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

3. Department of Pharmacology, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA.

4. Department of Antisense Drug Discovery, Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.

5. Cardiometabolic Phenotyping Core, Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA.

6. Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

7. Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

Depletion of Chop in pancreatic β cells optimizes insulin secretion and reduces fatty liver in preclinical models.

Funder

American Diabetes Association

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

University of California, San Diego

Diabetes Research Center

Australasian Delirium Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

1. Centers for Disease Control and Prevention National Diabetes Statistics Report (2017).

2. Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

3. An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass

4. A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

5. Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identifying patterns differing between high-dimensional datasets with generalized contrastive PCA;2024-08-09

2. Transcriptomic analysis of epicardial adipose tissue reveals the potential crosstalk genes and immune relationship between type 2 diabetes mellitus and atrial fibrillation;Gene;2024-08

3. Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus;Biomedicine & Pharmacotherapy;2024-08

4. α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway;Redox Biology;2024-08

5. AI-driven Discovery of Morphomolecular Signatures in Toxicology;2024-07-23