Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke-Reference-Cited by-同舟云学术

Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke

Published:2021-09-08 Issue:610 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Yuqing¹²^ORCID,Lu Shanshan¹^ORCID,Chen Yifei¹^ORCID,Li Liang¹^ORCID,Li Xia¹^ORCID,Qu Zhongwei²^ORCID,Huang Junbo²^ORCID,Fan Liu²,Yuan Chao¹^ORCID,Song Nan¹^ORCID,Zhang Jun³^ORCID,Xu Wendong³,Yang Shenglian¹^ORCID,Wang Yizheng¹³^ORCID

Affiliation:

1. The Brain Science Center, Beijing Institute of Basic Medical Sciences, 100850 Beijing, China.

2. Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, 200031 Shanghai, China.

3. Huashan Hospital, Fudan University, 200040 Shanghai, China.

Abstract

Activation of SHH pathway contributes to glutamate toxicity, and inhibition of SMO reduces ischemic brain damage in mice and monkeys.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference74 articles.

1. Mechanisms, challenges and opportunities in stroke