An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice-Reference-Cited by-同舟云学术

An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice

Published:2021-05-05 Issue:592 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kimura Takeshi¹^ORCID,Bosakova Michaela²³⁴^ORCID,Nonaka Yosuke⁵^ORCID,Hruba Eva⁴^ORCID,Yasuda Kie¹^ORCID,Futakawa Satoshi⁵^ORCID,Kubota Takuo¹^ORCID,Fafilek Bohumil²³⁴^ORCID,Gregor Tomas²³^ORCID,Abraham Sara P.²,Gomolkova Regina²⁴^ORCID,Belaskova Silvie³^ORCID,Pesl Martin²³⁶^ORCID,Csukasi Fabiana⁷⁸,Duran Ivan⁷⁸,Fujiwara Masatoshi⁵^ORCID,Kavkova Michaela⁹^ORCID,Zikmund Tomas⁹^ORCID,Kaiser Josef⁹^ORCID,Buchtova Marcela⁴¹⁰^ORCID,Krakow Deborah⁷^ORCID,Nakamura Yoshikazu⁵¹¹^ORCID,Ozono Keiichi¹^ORCID,Krejci Pavel²³⁴^ORCID

Affiliation:

1. Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan.

2. Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.

3. International Clinical Research Center, St. Anne’s University Hospital, 65691 Brno, Czech Republic.

4. Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic.

5. RIBOMIC Inc., Tokyo 108-0071, Japan.

6. First Department of Internal Medicine-Cardioangiology, St. Anne’s University Hospital, Masaryk University, 65691 Brno, Czech Republic.

7. Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.

8. Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN)-LABRET, University of Málaga, IBIMA-BIONAND, 29071 Málaga, Spain.

9. Central European Institute of Technology, Brno University of Technology, 61200 Brno, Czech Republic.

10. Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic.

11. Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Abstract

We report reversal of the FGFR3-related skeletal dysplasia by RNA aptamer designed to neutralize FGFR3 ligand FGF2.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Czech Science Foundation

Ministry of Education, Youth and Sports of the Czech Republic

the Japan Agency for Medical Research and Development

Agency for Healthcare Research of the Czech Republic

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. The birth prevalence rates for the skeletal dysplasias.

2. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

3. A novel variant of FGFR3 causes proportionate short stature

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5. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

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