Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Author:

Chrysostomou Stelios1ORCID,Roy Rajat1ORCID,Prischi Filippo23ORCID,Thamlikitkul Lucksamon14ORCID,Chapman Kathryn L.15,Mufti Uwais1ORCID,Peach Robert67ORCID,Ding Laifeng8ORCID,Hancock David9ORCID,Moore Christopher9ORCID,Molina-Arcas Miriam9ORCID,Mauri Francesco1,Pinato David J.1ORCID,Abrahams Joel M.1,Ottaviani Silvia1ORCID,Castellano Leandro1ORCID,Giamas Georgios10ORCID,Pascoe Jennifer11,Moonamale Devmini1ORCID,Pirrie Sarah12ORCID,Gaunt Claire12,Billingham Lucinda12,Steven Neil M.11ORCID,Cullen Michael11,Hrouda David13ORCID,Winkler Mathias13ORCID,Post John14ORCID,Cohen Philip14,Salpeter Seth J.15,Bar Vered15,Zundelevich Adi15ORCID,Golan Shay16ORCID,Leibovici Dan17,Lara Romain118ORCID,Klug David R.6ORCID,Yaliraki Sophia N.6,Barahona Mauricio19ORCID,Wang Yulan20ORCID,Downward Julian9ORCID,Skehel J. Mark21ORCID,Ali Maruf M.U.3ORCID,Seckl Michael J.1ORCID,Pardo Olivier E.1ORCID

Affiliation:

1. Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

2. School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK.

3. Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.

4. Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

5. Assay Biology, Domainex Ltd, Cambridge CB10 1XL, UK.

6. Department of Chemistry, Imperial College London, London SW7 2AZ, UK.

7. Department of Neurology, University Hospital Würzburg, 97080 Würzburg, Germany.

8. Key Laboratory of Magnetic Resonance in Biological Systems, National Centre for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

9. Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

10. Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.

11. Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.

12. Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK.

13. Department Urology, Charing Cross Hospital, London W6 8RF, UK.

14. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH. UK.

15. Curesponse, 6 Weizmann Street, 6423906 Tel Aviv, Israel.

16. Department of Urology, Rabin Medical Center, Jabotinsky St. 39, 4941492 Petah Tikva, Israel.

17. Department of Urology, Kaplan Medical Center, 7610001 Rehovot, Israel.

18. AstraZeneca, Discovery Science, R&D, Discovery Biology, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.

19. Department of Mathematics, Imperial College London, London SW7 2AZ, UK.

20. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.

21. Biological Mass Spectrometry and Proteomics, MRC LMB, Cambridge CB2 0QH, UK.

Abstract

RSK4 promotes invasiveness and drug resistance in lung and bladder cancer and inhibition of this kinase shows therapeutic potential.

Funder

University of Kentucky

Wellcome

Imperial Oil Limited

Engineering and Physical Sciences Research Council

Cancer Research UK

European Research Council

NIHR Imperial Biomedical Research Centre

Centro Singular de Investigación de Galicia

Cancer Treatment and Research Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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