Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury-Reference-Cited by-同舟云学术

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Published:2021-06-09 Issue:597 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Widjaja Anissa A.¹^ORCID,Dong Jinrui¹^ORCID,Adami Eleonora¹,Viswanathan Sivakumar¹^ORCID,Ng Benjamin¹²^ORCID,Pakkiri Leroy S.³,Chothani Sonia P.¹,Singh Brijesh K.¹^ORCID,Lim Wei Wen²^ORCID,Zhou Jin¹,Shekeran Shamini G.¹,Tan Jessie¹²,Lim Sze Yun²^ORCID,Goh Joyce¹,Wang Mao¹^ORCID,Holgate Robert⁴,Hearn Arron⁴^ORCID,Felkin Leanne E.⁵^ORCID,Yen Paul M.¹,Dear James W.⁶^ORCID,Drum Chester L.⁷⁸⁹^ORCID,Schafer Sebastian¹²,Cook Stuart A.¹²¹⁰^ORCID

Affiliation:

1. Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

2. National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.

3. Cardiac Department, National University Hospital, Singapore 119074, Singapore.

4. Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK.

5. National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.

6. Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.

7. Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore.

8. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

9. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

10. MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.

Abstract

Inhibition of IL11 signaling limits drug-induced liver damage and promotes hepatic regeneration in a mouse model.

Funder

National Medical Research Council

National University of Singapore

NUS-Agilent Hub for Translation and Capture

Fondation Leducq

Tanoto Foundation

MRC London institute of Medical Sciences

Goh Foundation

FUNDING

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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