An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients-Reference-Cited by-同舟云学术

An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients

Published:2020-07 Issue:550 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mann Joseph L.¹^ORCID,Maikawa Caitlin L.²^ORCID,Smith Anton A. A.¹³^ORCID,Grosskopf Abigail K.⁴^ORCID,Baker Sam W.⁵,Roth Gillie A.²^ORCID,Meis Catherine M.¹^ORCID,Gale Emily C.⁶^ORCID,Liong Celine S.²^ORCID,Correa Santiago¹^ORCID,Chan Doreen⁷^ORCID,Stapleton Lyndsay M.²^ORCID,Yu Anthony C.¹^ORCID,Muir Ben⁸^ORCID,Howard Shaun⁸^ORCID,Postma Almar⁸^ORCID,Appel Eric A.¹²⁹¹⁰^ORCID

Affiliation:

1. Department of Materials Science and Engineering, Stanford University, Stanford, CA 94025, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

3. Department of Science and Technology, Aarhus University, 8000 Aarhus, Denmark.

4. Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

5. Department of Comparative Medicine, Stanford University, Palo Alto, CA 94305, USA.

6. Department of Biochemistry, Stanford University, Palo Alto, CA 94305, USA.

7. Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

8. CSIRO Manufacturing, Clayton, VIC 3168, Australia.

9. ChEM-H Institute, Stanford University, Stanford, CA 94305, USA.

10. Department of Pediatrics (Endocrinology), Stanford University, Stanford, CA 94305, USA.

Abstract

Monomeric insulin stabilized with polymeric excipient exhibits increased stability and faster pharmacokinetics than current rapid-acting insulins.

Funder

U.S. Department of Defense

Novo Nordisk Fonden

NIDDK

NSERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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