Cardiac ryanodine receptor calcium release deficiency syndrome

Author:

Sun Bo12ORCID,Yao Jinjing1ORCID,Ni Mingke1ORCID,Wei Jinhong1,Zhong Xiaowei1,Guo Wenting1ORCID,Zhang Lin1,Wang Ruiwu1ORCID,Belke Darrell1,Chen Yong-Xiang1ORCID,Lieve Krystien V.V.34ORCID,Broendberg Anders K.5,Roston Thomas M.6ORCID,Blankoff Ivan7,Kammeraad Janneke A.8,von Alvensleben Johannes C.9,Lazarte Julieta10ORCID,Vallmitjana Alexander11ORCID,Bohne Loryn J.12,Rose Robert A.12,Benitez Raul11ORCID,Hove-Madsen Leif13ORCID,Napolitano Carlo41415ORCID,Hegele Robert A.10ORCID,Fill Michael16ORCID,Sanatani Shubhayan17ORCID,Wilde Arthur A.M.34ORCID,Roberts Jason D.18ORCID,Priori Silvia G.4141519ORCID,Jensen Henrik K.5ORCID,Chen S. R. Wayne116ORCID

Affiliation:

1. Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4Z6, Canada.

2. Medical School, Kunming University of Science and Technology, Kunming 650504, China.

3. Amsterdam University Medical Centre, location AMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam 1105AZ, Netherlands.

4. European Reference Network ‘ERN GUARD-Heart’, Amsterdam, Netherlands.

5. Department of Cardiology, Aarhus University Hospital, and Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Blv 99, DK-8200 Aarhus N, Denmark.

6. Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

7. C.H.U. Charleroi, Hôpital Civil Marie Curie Chaussée de Bruxelles 140 6042 Charleroi, Belgium.

8. Department of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus University Medical Centre, Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands.

9. Division of Cardiology, Heart Institute, Children’s Hospital Colorado, University of Colorado, Aurora, CO 80045, USA.

10. Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5B7, Canada.

11. Department of Automatic Control, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain.

12. Departments of Cardiac Sciences and Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.

13. Biomedical Research Institute Barcelona (IIBB-CSIC) and IIB Sant Pau, Hospital de Sant Pau, Barcelona 08025, Spain.

14. Division of Cardiology and Molecular Cardiology, IRCCS Maugeri Foundation-University of Pavia, 27100 Pavia, Italy.

15. Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.

16. Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL 60612, USA.

17. Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.

18. Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, ON N6A 5A5, Canada.

19. Molecular Cardiology Laboratory, Centro de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.

Abstract

Clinical and basic studies shed light on the mechanism, diagnosis, and treatment of cardiac ryanodine receptor Ca 2+ release deficiency syndrome.

Funder

Canadian Institutes of Health Research

Spanish Ministry of Science Innovation and Universities

Royal Netherlands Academy of Sciences

the E-Rare Joint Transnational Call for Proposals 2015 "Improving Diagnosis and Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: Integrating Clinical and Basic Science

the National Institutes of health

Heart and Stroke Foundation Chair in Cardiovascular Research

the European Research Council Grant “EU-rhythmy” ERC-ADG-2014

the Novo Nordisk Foundation, Denmark

the National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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