Loss of HDAC3 results in nonreceptive endometrium and female infertility

Author:

Kim Tae Hoon1ORCID,Yoo Jung-Yoon12ORCID,Choi Kyung-Chul34ORCID,Shin Jung-Ho5ORCID,Leach Richard E.16,Fazleabas Asgerally T.16,Young Steven L.7ORCID,Lessey Bruce A.8,Yoon Ho-Geun2ORCID,Jeong Jae-Wook16ORCID

Affiliation:

1. Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI 49534, USA.

2. Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, South Korea.

3. Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, South Korea.

4. Department of Pharmacology, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.

5. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Guro Hospital, Korea University Medical Center, Seoul 08318, South Korea.

6. Department of Women’s Health, Spectrum Health System, Grand Rapids, MI 49341, USA.

7. Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599, USA.

8. Obstetrics and Gynecology, Greenville Health System, Greenville, SC 29605, USA.

Abstract

Histone deacetylase 3 plays a critical role for early pregnancy through transcriptional regulation of COL1A1 and COL1A2 genes.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Research Foundation of Korea

Asian Institute for Life Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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