IRF7 inhibition prevents destructive innate immunity—A target for nonantibiotic therapy of bacterial infections

Author:

Puthia Manoj1,Ambite Ines1,Cafaro Caterina1,Butler Daniel1,Huang Yujing1,Lutay Nataliya1,Rydström Gustav1,Gullstrand Birgitta2,Swaminathan Bhairavi3,Nadeem Aftab1,Nilsson Björn34,Svanborg Catharina1

Affiliation:

1. Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, 223 62 Lund, Sweden.

2. Section of Rheumatology, Department of Clinical Sciences, Lund University and Skåne University Hospital, 221 85 Lund, Sweden.

3. Division of Hematology and Transfusion Medicine, Institute of Laboratory Medicine, Lund University, 223 62 Lund, Sweden.

4. Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Interferon regulatory factor 7 is an innate immune target for non–antibiotic-based immunotherapy for bacterial infection.

Funder

Swedish Research Council

Swedish Cancer Society

Soderberg Foundation

Knut and Alice Wallenberg Foundation

Osterlund and Sharon D. Lund Foundation

Anna-Lisa and Sven-Erik Lundgren Foundation

Maggie Stephens Foundation

H. J. Forssman Foundation

Medical Faculty of Lund University

Royal Physiographic Society

Network of Excellence

Infect-ERA

ALF (Avtal om Lakarutbildning och Forskning)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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