A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers-Reference-Cited by-同舟云学术

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers

Published:2017-01-04 Issue:371 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Stone Rivka C.¹²,Stojadinovic Olivera¹,Rosa Ashley M.¹,Ramirez Horacio A.¹³,Badiavas Evangelos¹⁴,Blumenberg Miroslav⁵,Tomic-Canic Marjana¹³⁶

Affiliation:

1. Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

2. Research Residency Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

3. Human Genetics and Genomics Graduate Program in Biomedical Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

4. Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

5. Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, NY 10012, USA.

6. John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Abstract

A bioengineered bilayered living cellular construct promotes ulcer healing by modulating inflammation, stimulating wound edge keratinocytes, and attenuating Wnt/β-catenin signaling to activate an acute wound response.

Funder

Organogenesis Inc.

NIH

Department of Dermatology and Cutaneous Surgery of the University of Miami Miller School of Medicine

University of Miami

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference24 articles.

1. Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement

2. Molecular Pathogenesis of Chronic Wounds