Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases-Reference-Cited by-同舟云学术

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

Published:2016-10-12 Issue:360 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rahbari Nuh N.¹²,Kedrin Dmitriy¹³,Incio Joao¹,Liu Hao¹,Ho William W.¹⁴,Nia Hadi T.¹,Edrich Christina M.¹,Jung Keehoon¹,Daubriac Julien¹,Chen Ivy¹⁵,Heishi Takahiro¹,Martin John D.¹,Huang Yuhui¹,Maimon Nir¹,Reissfelder Christoph²,Weitz Jurgen²,Boucher Yves¹,Clark Jeffrey W.⁶,Grodzinsky Alan J.⁷,Duda Dan G.¹,Jain Rakesh K.¹,Fukumura Dai¹

Affiliation:

1. Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

2. Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden 01307, Germany.

3. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

4. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

6. Department of Hematology/Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

7. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Anti-VEGF therapy enhances mechanical barriers to therapy in colorectal cancer liver metastases by increasing hyaluronan deposition.

Funder

NIH

American Cancer Society

German Research Foundation

Foundation for Science and Technology

Portuguese Human Potential Operational Program/European Social Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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