Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm

Author:

Nadadur Rangarajan D.1,Broman Michael T.2,Boukens Bastiaan34,Mazurek Stefan R.2,Yang Xinan1,van den Boogaard Malou4,Bekeny Jenna1,Gadek Margaret1,Ward Tarsha5,Zhang Min678910,Qiao Yun3,Martin James F.678910,Seidman Christine E.5,Seidman Jon5,Christoffels Vincent4,Efimov Igor R.3,McNally Elizabeth M.11,Weber Christopher R.1,Moskowitz Ivan P.1

Affiliation:

1. Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.

2. Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

3. Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.

4. Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.

5. Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

6. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

7. Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.

8. Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA.

9. Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

10. Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.

11. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

A mouse model reveals how seven atrial fibrillation–related risk genes form a network to control heartbeat.

Funder

NIH

The Leducq Foundation

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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