Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome-Reference-Cited by-同舟云学术

Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

Author:

Yang Zhantao¹,Keel Siobán B.¹,Shimamura Akiko²³,Liu Li¹,Gerds Aaron T.²,Li Henry Y.⁴,Wood Brent L.¹,Scott Bart L.²,Abkowitz Janis L.¹

Affiliation:

1. University of Washington, Seattle, WA 98195, USA.

2. Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Seattle Children’s Hospital, Seattle, WA 98105, USA.

4. Polyclinic, Seattle, WA 98104, USA.

Abstract

When heme synthesis exceeds globin synthesis, red blood cell differentiation fails, resulting in severe anemia.

Funder

NIH

Taub Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference48 articles.

2. Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia;Horos R.;Br. J. Haematol.,2012

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