Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration-Reference-Cited by-同舟云学术

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

Published:2017-06-21 Issue:395 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yaspan Brian L.¹^ORCID,Williams David F.²^ORCID,Holz Frank G.³,Regillo Carl D.⁴,Li Zhengrong¹,Dressen Amy¹^ORCID,van Lookeren Campagne Menno¹,Le Kha N.¹^ORCID,Graham Robert R.¹,Beres Tatiana¹^ORCID,Bhangale Tushar R.¹,Honigberg Lee A.¹,Smith Ashley¹,Henry Erin C.¹^ORCID,Ho Carole¹,Strauss Erich C.¹^ORCID,

Affiliation:

1. Genentech Inc., South San Francisco, CA 94080, USA.

2. VitreoRetinal Surgery, PA, Minneapolis, MN 55404, USA.

3. Department of Ophthalmology, University of Bonn, Bonn, Germany.

4. Wills Eye Hospital, Philadelphia, PA 19107, USA.

Abstract

The phase 2 MAHALO clinical trial shows that lampalizumab reduces geographic atrophy secondary to age-related macular degeneration and implicates complement dysregulation in disease pathogenesis.

Funder

Genentech Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference35 articles.

1. Age-related macular degeneration

2. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

3. Visual Function Abnormalities and Prognosis in Eyes with Age-related Geographic Atrophy of the Macula and Good Visual Acuity

4. Geographic Atrophy

5. Recent developments in the treatment of age-related macular degeneration

Cited by 150 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Progression Rate of Macular Retinal Pigment Epithelium Atrophy in Geographic Atrophy and Selected Inherited Retinal Dystrophies. A Systematic Review and Meta-Analysis;American Journal of Ophthalmology;2025-01

2. Association of Hyperautofluorescence Signals with Geographic Atrophy Progression in the METforMIN Trial;Ophthalmology Science;2024-09

3. Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration;Ophthalmology;2024-07

4. Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors;Journal of Biological Chemistry;2024-07

5. Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration;Science Translational Medicine;2024-06-05