α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease-Reference-Cited by-同舟云学术

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

Published:2016-06-08 Issue:342 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Di Maio Roberto¹²³,Barrett Paul J.¹²,Hoffman Eric K.¹²,Barrett Caitlyn W.¹²,Zharikov Alevtina¹²⁴,Borah Anupom¹⁵,Hu Xiaoping¹²,McCoy Jennifer¹²,Chu Charleen T.¹⁶,Burton Edward A.¹²⁴,Hastings Teresa G.¹²,Greenamyre J. Timothy¹²⁴

Affiliation:

1. Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.

2. Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

3. Ri.MED Foundation, Palermo, Italy.

4. Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.

5. Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India.

6. Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

The Parkinson’s disease–associated protein α-synuclein binds to the mitochondrial protein import receptor TOM20, which causes downstream impairment of mitochondrial function.

Funder

DSF Charitable Foundation

Ri.MED Foundation

Consolidated Anti-Aging Foundation

NIH

U.S. Department of Veterans Affairs

Blechman Foundation

American Parkinson Disease Association

Department of Biotechnology, Government of India

Publisher

American Association for the Advancement of Science (AAAS)

Subject