Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease-Reference-Cited by-同舟云学术

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Published:2016-05-25 Issue:340 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kumar Deepak Kumar Vijaya¹,Choi Se Hoon¹,Washicosky Kevin J.¹,Eimer William A.¹,Tucker Stephanie¹,Ghofrani Jessica¹,Lefkowitz Aaron¹,McColl Gawain²,Goldstein Lee E.³,Tanzi Rudolph E.¹,Moir Robert D.¹

Affiliation:

1. Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

2. The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.

3. Department of Psychiatry, Boston University, Boston, MA 02215, USA.

Abstract

β-Amyloid protein oligomerization and fibrillization, known to be pathogenic in Alzheimer’s disease, may play a physiological role in microbial entrapment and innate immunity.

Funder

NIH

Cure Alzheimer's Fund

The Helmsley Charitable Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference73 articles.

1. Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

2. Amyloid-β and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain

3. The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide