Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy

Author:

Polanco Maria Josè12,Parodi Sara23,Piol Diana1,Stack Conor3,Chivet Mathilde1,Contestabile Andrea2,Miranda Helen C.45,Lievens Patricia M.-J.6,Espinoza Stefano2,Jochum Tobias7,Rocchi Anna2,Grunseich Christopher3,Gainetdinov Raul R.89,Cato Andrew C. B.10,Lieberman Andrew P.11,La Spada Albert R.45,Sambataro Fabio12,Fischbeck Kenneth H.3,Gozes Illana13,Pennuto Maria12

Affiliation:

1. Dulbecco Telethon Institute, Centre for Integrative Biology, University of Trento, 38123 Trento, Italy.

2. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.

3. Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

4. Departments of Cellular and Molecular Medicine, Pediatrics, and Neurosciences, and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

5. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

6. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, 37134 Verona, Italy.

7. Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology, and abcr GmbH, Karlsruhe, Germany.

8. Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.

9. Skolkovo Institute of Science and Technology, Skolkovo, 143025 Moscow, Russia.

10. Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany.

11. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

12. Department of Experimental and Clinical Medical Sciences (DISM), University of Udine, 33100 Udine, Italy.

13. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel.

Abstract

Adenylyl cyclase activating polypeptide modifies androgen receptor phosphorylation and spinal and bulbar muscular atrophy pathogenesis.

Funder

Kennedy’s Disease Association

Muscular Dystrophy Association

Telethon-Italy and Provincia Autonoma di Trento–Italy

Bando Progetti Strategici di Ateneo–University of Trento

Marie Curie Reintegration

Italian Ministry of Health

Association Française contre les Myopathies

Russian Science Foundation

NIH

Fondazione Umberto Veronesi

Marie Curie International Outgoing Fellowships

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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