Insights into neuroepigenetics through human histone deacetylase PET imaging-Reference-Cited by-同舟云学术

Insights into neuroepigenetics through human histone deacetylase PET imaging

Published:2016-08-10 Issue:351 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wey Hsiao-Ying¹,Gilbert Tonya M.¹,Zürcher Nicole R.¹,She Angela²,Bhanot Anisha¹,Taillon Brendan D.¹,Schroeder Fredrick A.¹,Wang Changing¹,Haggarty Stephen J.²,Hooker Jacob M.¹

Affiliation:

1. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

2. Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Abstract

First-in-human neuroepigenetic PET imaging with [ 11 C]Martinostat reveals conserved region-specific expression of class I HDACs in the healthy brain.

Funder

National Institute on Drug Abuse

Department of Energy

National Institute of Biomedical Imaging and Bioengineering

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference40 articles.

1. Histone deacetylases in memory and cognition

2. The many roles of histone deacetylases in development and physiology: implications for disease and therapy