A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine-Reference-Cited by-同舟云学术

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

Published:2017-03-08 Issue:380 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Schumann Benjamin¹²^ORCID,Hahm Heung Sik¹²^ORCID,Parameswarappa Sharavathi G.¹^ORCID,Reppe Katrin³,Wahlbrink Annette¹^ORCID,Govindan Subramanian¹^ORCID,Kaplonek Paulina¹²^ORCID,Pirofski Liise-anne⁴,Witzenrath Martin³^ORCID,Anish Chakkumkal¹,Pereira Claney L.¹^ORCID,Seeberger Peter H.¹²^ORCID

Affiliation:

1. Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam, Germany.

2. Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany.

3. Division of Pulmonary Inflammation, Department of Infectious Diseases and Pulmonary Medicine, Charité–Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

4. Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Abstract

Automated glycan assembly enabled antibody reverse engineering to develop a semisynthetic carbohydrate–based vaccine against the highly virulent Streptococcus pneumoniae serotype 8.

Funder

National Institutes of Health

European Research Council

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. B. Schumann C. Anish C. L. Pereira P. H. Seeberger in Biotherapeutics: Recent Developments Using Chemical and Molecular Biology RSC Drug Discovery Series No. 36 L. Jones A. J. McKnight Eds. (RSC Publishing 2013) pp. 68–104.

2. Germline antibody recognition of distinct carbohydrate epitopes