Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson’s disease

Author:

Won So-Yoon1,Park Mee-Hee1,You Soon-Tae1,Choi Seung-Won1,Kim Hyong-Kyu2,McLean Catriona3,Bae Suk-Chul4,Kim Sang Ryong56,Jin Byung Kwan7,Lee Kun Ho89,Shin Eun-Young1,Kim Eung-Gook1

Affiliation:

1. Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 28644, South Korea.

2. Department of Medicine and Microbiology, College of Medicine, Chungbuk National University, Cheongju 28644, South Korea.

3. Department of Pathology, The Alfred Hospital, Melbourne, Victoria 3004, Australia.

4. Department of Biochemistry, School of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju 28644, South Korea.

5. School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, South Korea.

6. Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, South Korea.

7. Department of Biochemistry & Molecular Biology, Department of Neuroscience, Neurodegeneration Control Research Center, School of Medicine, Kyung Hee University, Seoul 02447, South Korea.

8. National Research Center for Dementia, Chosun University, Gwangju 61452, South Korea.

9. Department of Biomedical Science, Chosun University, Gwangju 61452, South Korea.

Abstract

PAK4-CRTC1 signaling in dopaminergic neurons mediates neuroprotection in rodent models of Parkinson’s disease.

Funder

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference67 articles.

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2. Parkinson's Disease

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5. Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy

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