High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Author:

Sharma Arun123ORCID,Burridge Paul W.124,McKeithan Wesley L.156,Serrano Ricardo7ORCID,Shukla Praveen123,Sayed Nazish123,Churko Jared M.123,Kitani Tomoya123ORCID,Wu Haodi123,Holmström Alexandra123,Matsa Elena123,Zhang Yuan123,Kumar Anusha123,Fan Alice C.8,del Álamo Juan C.7,Wu Sean M.123,Moslehi Javid J.9,Mercola Mark135ORCID,Wu Joseph C.123ORCID

Affiliation:

1. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Department of Pharmacology and Center for Pharmacogenomics, Northwestern University School of Medicine, Chicago, IL 60611, USA.

5. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

6. Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

7. Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA.

8. Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

9. Division of Cardiovascular Medicine, Cardio-Oncology Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA.

Abstract

High-throughput screening of drugs with human induced pluripotent stem cell–derived cardiomyocytes reveals a “cardiac safety index.”

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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