Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice-Reference-Cited by-同舟云学术

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Published:2017-05-31 Issue:392 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shi Qiaoqiao¹²^ORCID,Chowdhury Saba¹^ORCID,Ma Rong¹^ORCID,Le Kevin X.¹^ORCID,Hong Soyon²³^ORCID,Caldarone Barbara J.²⁴,Stevens Beth²³^ORCID,Lemere Cynthia A.¹²^ORCID

Affiliation:

1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

2. Harvard Medical School, Boston, MA 02115, USA.

3. Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Center for Life Sciences, 12th Floor, 300 Longwood Avenue, Boston, MA 02115, USA.

4. Harvard NeuroDiscovery Center NeuroBehavior Laboratory, Department of Neurology, Brigham and Women’s Hospital, Harvard Institute of Medicine, Room 945, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Abstract

C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant Aβ plaques.

Funder

National Institute on Aging

BrightFocus Foundation

Fidelity Biosciences

Edward R and Anne G Lefler

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference69 articles.