Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

Author:

Dey Devaveena1,Bagarova Jana1,Hatsell Sarah J.2,Armstrong Kelli A.1,Huang Lily2,Ermann Joerg3,Vonner Ashley J.1,Shen Yue1,Mohedas Agustin H.1,Lee Arthur4,Eekhoff Elisabeth M. W.5,van Schie Annelies5,Demay Marie B.6,Keller Charles7,Wagers Amy J.89,Economides Aris N.210,Yu Paul B.1

Affiliation:

1. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

2. Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

3. Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

5. Departments of Internal Medicine, Endocrine Section, and Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, Netherlands.

6. Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

7. Children’s Cancer Therapy Development Institute, 12655 SW Beaverdam Road-West, Beaverton, OR 97005, USA.

8. Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

9. Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

10. Regeneron Genetics Center, Tarrytown, NY 10591, USA.

Abstract

Tissue-specific manifestations of the congenital bone-forming syndrome FOP are mediated by multiple tissue-resident stem cell populations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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