Selective targeting of mutant adenomatous polyposis coli ( APC ) in colorectal cancer-Reference-Cited by-同舟云学术

Selective targeting of mutant adenomatous polyposis coli ( APC ) in colorectal cancer

Published:2016-10-19 Issue:361 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Lu¹,Theodoropoulos Panayotis C.²,Eskiocak Ugur³,Wang Wentian²,Moon Young-Ah⁴,Posner Bruce²,Williams Noelle S.²,Wright Woodring E.¹,Kim Sang Bum¹,Nijhawan Deepak²⁵⁶,De Brabander Jef K.²,Shay Jerry W.¹

Affiliation:

1. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

3. Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

4. Department of Molecular Medicine, Inha University College of Medicine, 100 Inha-ro, Nam-gu, Incheon 22212, Korea.

5. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

6. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

A small molecule specifically kills cancer cells with APC truncations and spares cells with wild-type APC.

Funder

Cancer Prevention Research Institute of Texas

NIH

National Research Foundation of Korea

UT Southwestern HTS Core

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. Biology of the Adenomatous Polyposis Coli Tumor Suppressor

2. APC mutations occur early during colorectal tumorigenesis

3. Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

4. The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.

5. A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. GAS6-AS1 drives bladder cancer progression by increasing MMP7 expression in a ceRNA- and RBP-dependent manner;Translational Oncology;2024-10

2. Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor;Lung Cancer;2024-06

3. Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors;Journal of Biological Chemistry;2024-06

4. Associations between “Cancer Risk”, “Inflammation” and “Metabolic Syndrome”: A Scoping Review;Biology;2024-05-16

5. Chemical Inhibition of Sterol Biosynthesis;Biomolecules;2024-03-28