Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages-Reference-Cited by-同舟云学术

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

Published:2016-04-27 Issue:336 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Ruijun¹,Verkoczy Laurent¹²³,Wiehe Kevin¹³,Munir Alam S.¹²³,Nicely Nathan I.¹,Santra Sampa⁴,Bradley Todd¹³,Pemble Charles W.¹,Zhang Jinsong¹,Gao Feng¹³,Montefiori David C.¹⁵,Bouton-Verville Hilary¹,Kelsoe Garnett¹⁶,Larimore Kevin⁷,Greenberg Phillip D.⁷,Parks Robert¹,Foulger Andrew¹,Peel Jessica N.¹,Luo Kan¹,Lu Xiaozhi¹,Trama Ashley M.¹,Vandergrift Nathan¹³,Tomaras Georgia D.¹⁵,Kepler Thomas B.⁸,Moody M. Anthony¹⁶⁹,Liao Hua-Xin¹³,Haynes Barton F.¹²³

Affiliation:

1. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2. Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

3. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

4. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

5. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

6. Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

7. Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA.

8. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

9. Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

Immune tolerance mechanisms limit gp41 neutralizing antibody lineage maturation to broadly neutralizing antibodies.

Funder

Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery

NIH

National Institute of Allergy and Infectious Diseases

Division of AIDS and Collaboration for AIDS Vaccine Discovery

Bill & Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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