An oral microjet vaccination system elicits antibody production in rabbits

Author:

Aran Kiana1234ORCID,Chooljian Marc135ORCID,Paredes Jacobo136ORCID,Rafi Mohammad1,Lee Kunwoo15,Kim Allison Y.1,An Jeanny1ORCID,Yau Jennifer F.1,Chum Helen7ORCID,Conboy Irina145,Murthy Niren135ORCID,Liepmann Dorian135ORCID

Affiliation:

1. Department of Bioengineering, University of California (UC), Berkeley, Berkeley, CA 94720, USA.

2. School of Applied Life Sciences, Keck Graduate Institute, Claremont, CA 91711, USA.

3. Berkeley Sensor and Actuator Center, Berkeley, CA 94720, USA.

4. Buck Institute for Research on Aging, Novato, CA 94945, USA.

5. UC Berkeley–UC San Francisco Graduate Program in Bioengineering, Berkeley and San Francisco, CA 94158, USA.

6. Center of Studies and Technical Research of Gipuzkoa and Tecnun (Technological Campus of the University of Navarra), 20018 San Sebastián, Spain.

7. Office of Laboratory Animal Care, UC Berkeley, Berkeley, CA 94720, USA.

Abstract

A needle-free device delivers a liquid jet of vaccine that penetrates the buccal mucosa and elicits antibody production in rabbits.

Funder

Campisi/Ellerby

Berkeley Sensor and Actuator Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference32 articles.

1. Vaccine Delivery to the Oral Cavity Using Coated Microneedles Induces Systemic and Mucosal Immunity

2. Needle-free vaccine delivery☆

3. Vaccines for pandemic influenza. Preface;Compans R. W.;Curr. Top. Microbiol. Immunol.,2009

4. Vaccine and needle-free vaccination delivery system;Ren T.;J. Microb. Biochem. Technol.,2014

5. B. Wang T. J. Siahaan R. Soltero Drug Delivery: Principles and Applications (John Wiley & Sons 2005).

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