NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

Author:

Ryu Dongryeol1,Zhang Hongbo1,Ropelle Eduardo R.12,Sorrentino Vincenzo1,Mázala Davi A. G.3,Mouchiroud Laurent1,Marshall Philip L.4,Campbell Matthew D.5,Ali Amir Safi5,Knowels Gary M.5,Bellemin Stéphanie6,Iyer Shama R.7,Wang Xu1,Gariani Karim1,Sauve Anthony A.8,Cantó Carles9,Conley Kevin E.5,Walter Ludivine6,Lovering Richard M.7,Chin Eva R.3,Jasmin Bernard J.10,Marcinek David J.5,Menzies Keir J.14,Auwerx Johan1

Affiliation:

1. Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

2. Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.

3. Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.

4. Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute and Centre for Neuromuscular Disease, Ottawa, Ontario K1H 8M5, Canada.

5. Department of Radiology, University of Washington, Seattle, WA 98195, USA.

6. Centre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.

7. Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

8. Department of Pharmacology, Weill Cornell Medical School, New York, NY 10065, USA.

9. Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.

10. Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

Abstract

NAD + treatment can reverse the functional decline in degenerating muscles.

Funder

Heart and Stroke Foundation of Canada

NIH

Krebsforschung Schweiz/Swiss Cancer League

Systems X

Swiss National Science Foundation

Horizon 2020

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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