Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Author:

Thorek Daniel L. J.12,Watson Philip A.3,Lee Sang-Gyu2,Ku Anson T.2,Bournazos Stylianos4,Braun Katharina5,Kim Kwanghee6,Sjöström Kjell7,Doran Michael G.2,Lamminmäki Urpo8,Santos Elmer2,Veach Darren29,Turkekul Mesruh10,Casey Emily11,Lewis Jason S.1112,Abou Diane S.1,van Voss Marise R. H.113,Scardino Peter T.614,Strand Sven-Erik15,Alpaugh Mary L.16,Scher Howard I.1718,Lilja Hans617192021,Larson Steven M.29,Ulmert David61122

Affiliation:

1. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

2. Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Leonard Wagner Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065, USA.

5. Department of Urology, University Hospital of the Ruhr-University of Bochum, Marien Hospital Herne, Herne, Germany.

6. Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Innovagen AB, Lund, Sweden.

8. Department of Biochemistry, University of Turku, Turku, Finland.

9. Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA.

10. Molecular Cytology Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

11. Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

12. Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

13. Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.

14. Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA.

15. Department of Medical Radiation Physics, Lund University, Lund, Sweden.

16. Departments of Biology and Biomedical and Translational Sciences, Rowan University, Glassboro, NJ 08028, USA.

17. Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

18. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

19. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

20. Nuffield Department of Surgical Sciences, University of Oxford, Oxford, U.K.

21. Department of Laboratory Medicine, Lund University, Malmö, Sweden.

22. Division of Urological Research, Department of Clinical Sciences, Lund University, Malmö, Sweden.

Abstract

A radiolabeled antibody against a secreted antigen uses Fc receptor–mediated internalization for cancer imaging and therapy.

Funder

NIH

Geoffrey Beene Cancer Research Center

Radiochemistry and Molecular Imaging Probe Core

NIH Molecular Imaging Fellowship Program

Knut and Alice Wallenberg Foundation

Bertha Kamprad Foundation

Swedish National Health Foundation

National Cancer Institute

National Institute for Health Research

Swedish Cancer Society

Swedish Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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