Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function-Reference-Cited by-同舟云学术

Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function

Published:2017-02-08 Issue:376 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hilgers Rob H. P.¹,Kundumani-Sridharan Venkatesh¹,Subramani Jaganathan¹,Chen Leon C.¹,Cuello Luis G.²,Rusch Nancy J.³,Das Kumuda C.¹

Affiliation:

1. Department of Anesthesiology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6598, Lubbock, TX 79430, USA.

2. Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

3. Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 Markham Street, Little Rock, AR 72205, USA.

Abstract

Thioredoxin treatment in aged mice reversed hypertension, suggesting a potential therapeutic approach.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Endothelial dysfunction and hypertension in aging

2. The aging hypertensive heart: a brief update

3. Should Patients With Cardiovascular Risk Factors Receive Intensive Treatment of Hypertension to <120/80 mm Hg Target?

4. Management of hypertension in the elderly

5. Oxidative Stress, Nitric Oxide Synthase, and Superoxide Dismutase

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Redox Regulation of K⁺ Channel: Role of Thioredoxin;Antioxidants & Redox Signaling;2024-08-28

2. Reactive oxygen species in hypertension;Nature Reviews Cardiology;2024-07-24

3. Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases;Redox Biology;2024-04

4. Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology;Antioxidants & Redox Signaling;2024-03-01

5. Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease;Ageing Research Reviews;2023-09