A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise-Reference-Cited by-同舟云学术

A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise

Published:2024-09-04 Issue:763 Volume:16 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cho Soongwon¹²^ORCID,Shaban Samy M.³⁴⁵^ORCID,Song Ruihao¹⁶^ORCID,Zhang Haohui⁷^ORCID,Yang Dasom¹⁸^ORCID,Kim Min-Jae³⁴,Xiong Yirui¹⁹,Li Xiuyuan⁷,Madsen Kenneth²¹⁰^ORCID,Wapnick Sarena¹¹,Zhang Shifan¹²^ORCID,Chen Ziyu⁹^ORCID,Kim Jiwon¹²³^ORCID,Guinto Gianna¹³,Li Michelle¹¹,Lee Minkyu¹¹⁴¹⁵^ORCID,Nuxoll Ravi F.¹⁹¹⁶^ORCID,Shajari Shaghayegh¹²,Wang Jin¹²⁹¹⁷^ORCID,Son Seongeun¹⁸^ORCID,Shin Jihoon³⁴,Aranyosi Alexander J.¹²¹⁹^ORCID,Wright Donald E.¹⁹^ORCID,Kim Tae-il³⁴^ORCID,Ghaffari Roozbeh¹²¹¹¹⁹,Huang Yonggang¹⁷⁹²⁰^ORCID,Kim Dong-Hwan³⁴^ORCID,Rogers John A.¹²⁹¹¹²¹^ORCID

Affiliation:

1. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.

2. Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

3. School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

4. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea.

5. Petrochemical Department, Egyptian Petroleum Research Institute, Cairo, 11727, Egypt.

6. Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.

7. Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

8. Precision Biology Research Center (PBRC), Sungkyunkwan University, Suwon, 16419, Republic of Korea.

9. Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

10. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

11. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

12. Department of Statistics, School of Computer, Data and Information Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

13. College of Science and Health, DePaul University, Chicago, IL 60614, USA.

14. Shirley Ryan AbilityLab, Chicago, IL 60611, USA.

15. Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611, USA.

16. Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.

17. Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

18. Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Republic of Korea.

19. Epicore Biosystems, Cambridge, MA 02139, USA.

20. Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

21. Department of Neurological Surgery, Northwestern University, Evanston, IL 60208, USA.

Abstract

Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve similar purposes and offers the advantage of noninvasive collection and continuous monitoring. The relationship between blood lactate and dynamic sweat biochemistry for wearable engineering applications in physiological fitness remains poorly defined. Here, we developed a microfluidic wearable band with an integrated colorimetric timer and biochemical assays that temporally captures sweat and measures pH and lactate concentration. A colorimetric silver nanoplasmonic assay was used to measure the concentration of lactate, and dye-conjugated SiO 2 nanoparticle–agarose composite materials supported dynamic pH analysis. We evaluated these sweat biomarkers in relation to blood lactate in human participant studies during cycling exercise of varying intensity. Iontophoresis-generated sweat pH from regions of actively working muscles decreased with increasing heart rate during exercise and was negatively correlated with blood lactate concentration. In contrast, sweat pH from nonworking muscles did not correlate with blood lactate concentration. Changes in sweat pH and blood lactate were observed in participants who did not regularly exercise but not in individuals who regularly exercised, suggesting a relationship to physical fitness and supporting further development for noninvasive, biochemical fitness evaluations.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/scitranslmed.ado5366

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